Widespread evasion of posttranscriptional regulation associated with proliferation
by
Rickard Sandberg(Department of Cell and Molecular Biology, KI)
→
Europe/Stockholm
Description
The stability, localization and translation of mammalian mRNAs are largely determined by sequences in the 3' untranslated region (UTR). Using exon microarrays, we identified a gene regulatory program of increased upstream polyadenylation site usage following activation of primary murine CD4+ T lymphocytes. This program, resulting in shorter 3' UTRs, is conserved across cell types and species and influence the protein expression levels. Together, our data indicate that polyadenylation site usage is coordinately regulated such that states of increased proliferation are associated with widespread reduction of 3' UTR-based regulation.