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About 400 km above us a unique laboratory is orbiting around the Earth. Although its first pieces were launched in November 1998 and it has been permanently manned since late 2000, it is still less than half completed, partly due to the grounding of the space shuttle fleet after the Columbia accident two years ago. However, with the shuttle expected to return-to-flight in May, the construction should soon continue and be completed in 2010. Although ISS is built as a laboratory for a variety of sciences from life sciences to fundamental physics, it is a testing ground for future space exploration. This seminar will discuss the construction of ISS, technical as well as political challenges, and the exploitation of the space station.