Seminar room RB35 (Roslagstullsbacken 35, the SBC house)
Description
Cancer is a complex disease in which cells are transformed, through acquisition of different aberrations, to malignant types that are able to divide, invade, and metastasize. During the course of the disease, malignant tumors are able to acquire traits enabling the growth, sustenance, and spread of tumors within the body. To properly understand a certain cancer form, we need a representation of its patterns of possible progression.
A simple descriptive path model of colon cancer was suggested by Vogelstein in 1988. In recent years, several mathematical models for cancer progression have been suggested, often using directed trees as a basis. I will present HOTs, hidden-variable oncogenetic trees, that can be used to infer models of cancer progression from high-throughput data.
