New challenges and methods for prediction of membrane protein topology

by Arne Elofsson (SBC/CBR)

Wednesday 27 Feb 2008, 16:00 → 17:00 Europe/Stockholm

RB35 (Seminar room RB35)

Since high-resolution structural data are still scarce, different kinds of theoretical structure prediction algorithms are of major importance in membrane protein biochemistry. But how well do the current prediction methods perform? Which structural features can be predicted and which cannot? And what can we expect in the next few years? Here, we will try to answer these questions, with a particular focus on the new types of substructures found in recently solved membrane protein structures, including reeentrant regions.