Genomic signatures for the emergence, development and diversification of the TGF-beta/BMP signaling pathway within the animal kingdom
by
Lukasz Huminiecki(KI)
→
Europe/Stockholm
RB35
RB35
Seminar room RB35 (Roslagstullsbacken 35, the SBC house)
Description
The profound question of how genomic processes, such as gene duplication and losses, give rise to co-ordinated organismal properties, such as emergence of new body plans, organs and lifestyles, is of paramount importance in developmental and evolutionary biology. I will focus on the diversification of the transforming growth factor-b (TGF-b) pathway . one of the most fundamental and versatile metazoan signal transduction engines. Our results challenge the view of well-conserved developmental pathways. TGF-b signal transduction engine has expanded through gene duplication, continually accomplishing new functions, as animals grew in anatomical complexity, colonized new environments, and developed an active immune system.
