PET is an imaging modality that uses externally-detectable radiolabeled molecules to track biochemical processes in vivo. Functional information can be obtained in a living subject throughout a desired observation time interval. Repeated and consequently longitudinal studies can potentially be performed in any given individual. Each subject will then be it’s own control. The technique has been used in basic research since the late 1970’s and over the past 10 years has emerged as a very valuable tool in the diagnosis and treatment of cancer patients. Recently we have also acquired a microPET scanner and a facility has been established for the non-invasive, quantitative and repetitive imaging of biological function in living small animals (mice, rats, guinea pigs). This talk will describe our aims and experiences with trying to integrate clinical and preclinical PET and thereby establish methods for systematically studying across species disease processes and the therapeutic strategies being designed to remedy them.
