Prediction, detection and functional analysis of ncRNAs
by
MrAymeric Fouquier d'Herouel(KTH Computational Biology)
→
Europe/Stockholm
RB 35
RB 35
Description
Non-coding (nc) RNAs are emerging as important and surprisingly
ubiquitous players in gene regulation across all kingdoms, adding new
layers of complexity to the regulatory machinery. Beside challenging
views about the junk content of higher organisms' genomes and opening
possible explanations to the riddle of high complexity vs low gene
number observed in many organisms, recently unveiled functions of ncRNA
open exciting questions to a broad community of interdisciplinary
research.
The talk consists of two main parts: first, I present the current state
of a genome wide computational and experimental ncRNA and target search
in the genome of Enterococcus faecalis which so far revealed a couple of
non-coding transcripts. Functional analysis is ongoing on these
candidates, yet first results exhibit highly interesting regulatory
properties.
Second, I argue how the computational method of our choice
may be applicable to some extent to eukaryotic and viral genomes. The
work is performed in collaboration with Institut Pasteur, the French
National Institute for Agricultural Research (INRA) and the Department
of Microbiology, Tumor and Cell Biology, Karolinska Institutet.
