[ScientiFika] Inside a Brain Infection: Understanding Pneumococcal Meningitis and How We’re Fighting It

by Simona Serra (Karolinska Institute)

Friday 21 Nov 2025, 16:00 → 17:30 Europe/Stockholm

Floor 6 - Fika Area (AlbaNova Main Building)

What actually happens inside the brain during a severe infection? In my research, I explore one of the most dangerous infections: pneumococcal meningitis, a fast-moving disease that causes intense inflammation and can leave lasting neurological problems.I study how Streptococcus pneumoniae harms the brain, focusing on two key parts of this process.

First, I work on Annexin A1, an exciting new molecule that shows promise as both a powerful antimicrobial and a protector of brain cells---a hopeful step forward in a world facing rising antibiotic resistance.

I also investigate pneumolysin, the toxin the bacteria use as their main weapon. By comparing toxins found in patients to the standard laboratory strain, I’ve found that real-world versions are released more easily and are far more damaging to neurons.

So let’s dive in together and explore what makes this infection so dangerous---and what we’re doing to fight it!

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Note: This event is open to the junior audience only, including undergraduate, master’s, and PhD students, as well as postdocs.