In order to enable an iCal export link, your account needs to have an API key created. This key enables other applications to access data from within Indico even when you are neither using nor logged into the Indico system yourself with the link provided. Once created, you can manage your key at any time by going to 'My Profile' and looking under the tab entitled 'HTTP API'. Further information about HTTP API keys can be found in the Indico documentation.
Additionally to having an API key associated with your account, exporting private event information requires the usage of a persistent signature. This enables API URLs which do not expire after a few minutes so while the setting is active, anyone in possession of the link provided can access the information. Due to this, it is extremely important that you keep these links private and for your use only. If you think someone else may have acquired access to a link using this key in the future, you must immediately create a new key pair on the 'My Profile' page under the 'HTTP API' and update the iCalendar links afterwards.
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(University of Groningen, KVI Atomic Physics)
The current increasing social and corporate interest in proton- and heavy ion-therapy of malignant tumours lead to an increasing number of treatment facilities worldwide. When fast ions traverse tissue and are decelerated to MeV energies and below, the so-called Bragg-peak is reached. At this well-defined depth, damage is highest due to maximum linear energy transfer and radiobiological effectiveness at these energies. This volume sensitivity renders ion-therapy a superior tool for a number of tumors, often decreasing the yearly risk of radiation induced development of lethal secondary tumors by up to one order of magnitude!
The chemical and biological aspects of biological radiation damage have been studied in great detail. Whereas for conventional radiation the molecular mechanisms underlying biological action are to some extent understood, the exceptional cell killing efficiency of heavy ions and protons is largely unexplored on the molecular level.
In Groningen we recently observed fragment ion kinetic energies exceeding 10 eV when irradiating isolated DNA building blocks with ions at Bragg-peak energies. Such energetic fragments can in turn induce further ionization and fragmentation of DNA building blocks, leading to an avalanche of damage that could manifest in clustered DNA lesions.
Currently, more complex targets such as electrosprayed nanosolvated biomolecules and biomolecular complexes are employed to extend radiation damage studies to more realistic systems. First results indicate that a chemical environment opens up additional fragmentation channels for DNA building blocks. Water solvation shells, on the other hand, seem to prevent fragmentation.