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A compartmental model of a spiking and adapting olfactory receptor neuron for use in large-scale neuronal network models of the olfactory system.
Clàudia Ramos Garcia
In the aim of obtaining complete models of the biological olfactory system it is necessary to develop models of each one of its parts: the olfactory epithelium (with olfactory receptor neurons), the olfactory bulb and the olfactory cortex.
This thesis deals with the development of a model of the olfactory epithelium suitable for network simulations; in the form of a set of olfactory receptor neurons (ORNs) expressing different kind and amount of olfactory receptors. The developed ORN model is a single cell model at a very low level of abstraction, including Hodgkin-Huxley type ion channels.
Taking experimental data as a reference, in this model I try to represent a good compromise between simplicity and biological plausibility.