Speaker
Heiner Linke
(Nanometer Structure Consortium, Lund University)
Description
In so-called motility assays, a surface is coated with
functional motor proteins (such as myosin or kinesin) and
filaments (such as actin or microtubules) are propelled
along the surface, powered by ATP. In close collaboration
with Alf Månsson at the Linné University in Kalmar, we are
exploring the development of functional, nanostructured
devices based on such assays.
For example, motors can be used to actively concentrate
analyte for enhanced detection in diagnostics [1] , and we
demonstrated the use of motor proteins to characterize
light-guiding in nanowires that leads to a novel concept for
enhanced, optical biosensing [2]. I will also report on an
ongoing project to use molecular motors for massively
parallel biocomputation, a project for which we are
developing functional elements such as gates [3] and tunnels
[4], allowing the crossing of nanochannels guiding motor
proteins in a lab-on-a-chip application.
[1] Lard, M. et al. Ultrafast molecular motor driven
nanoseparation and biosensing. Biosens. Bioelectron. 48,
145-152 (2013).
[2] ten Siethoff, L., Lard, M., Generosi, J., Andersson, H.
S., Linke, H., Månsson, A. Molecular motor propelled
filaments reveal light-guiding efficiency in nanowire arrays
for enhanced biosensing. Nano Lett. 14(2), 737-742 (2013)
doi: 10.1021/nl404032k.
[3] Schroeder, V., Korten, T., Linke, H., Diez, S., &
Maximov, I. (2013). Dynamic Guiding of Motor-Driven
Microtubules on Electrically Heated, Smart Polymer Tracks.
Nano Letters, 13(7), 3434–3438 (2013). doi:10.1021/nl402004s
[4] Lard, M., ten Siethoff, L., Generosi, J., Månsson, A.,
Linke, H. Molecular motor transport through hollow
nanowires. Submitted (2014).
