Mar 26 – 28, 2014
Nordita, Stockholm
Europe/Stockholm timezone

Engineering with molecular motors

Mar 27, 2014, 11:45 AM
45m
132:028 (Nordita, Stockholm)

132:028

Nordita, Stockholm

Speaker

Heiner Linke (Nanometer Structure Consortium, Lund University)

Description

In so-called motility assays, a surface is coated with functional motor proteins (such as myosin or kinesin) and filaments (such as actin or microtubules) are propelled along the surface, powered by ATP. In close collaboration with Alf Månsson at the Linné University in Kalmar, we are exploring the development of functional, nanostructured devices based on such assays. For example, motors can be used to actively concentrate analyte for enhanced detection in diagnostics [1] , and we demonstrated the use of motor proteins to characterize light-guiding in nanowires that leads to a novel concept for enhanced, optical biosensing [2]. I will also report on an ongoing project to use molecular motors for massively parallel biocomputation, a project for which we are developing functional elements such as gates [3] and tunnels [4], allowing the crossing of nanochannels guiding motor proteins in a lab-on-a-chip application. [1] Lard, M. et al. Ultrafast molecular motor driven nanoseparation and biosensing. Biosens. Bioelectron. 48, 145-152 (2013). [2] ten Siethoff, L., Lard, M., Generosi, J., Andersson, H. S., Linke, H., Månsson, A. Molecular motor propelled filaments reveal light-guiding efficiency in nanowire arrays for enhanced biosensing. Nano Lett. 14(2), 737-742 (2013) doi: 10.1021/nl404032k. [3] Schroeder, V., Korten, T., Linke, H., Diez, S., & Maximov, I. (2013). Dynamic Guiding of Motor-Driven Microtubules on Electrically Heated, Smart Polymer Tracks. Nano Letters, 13(7), 3434–3438 (2013). doi:10.1021/nl402004s [4] Lard, M., ten Siethoff, L., Generosi, J., Månsson, A., Linke, H. Molecular motor transport through hollow nanowires. Submitted (2014).

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