Mar 26 – 28, 2014
Nordita, Stockholm
Europe/Stockholm timezone

Vorticity Patterns in Tissues induced by Cell Divisions

Mar 26, 2014, 2:00 PM
45m
132:028 (Nordita, Stockholm)

132:028

Nordita, Stockholm

Speaker

Mogens Hogh Jensen (The Niels Bohr Institute, University of Copenhagen)

Description

In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. We study the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots [1]. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. We model these observations by a hydrodynamic continuum model simulating division as a local pressure increase in a non-nematic, meso-scale turbulent state [1]. In order to describe the injected energy by cell motion in the tissue we assume a negative local viscosity stabilized by a higher order term. We find a vorticity pattern very similar to the experimental observations with a similar order and periodicity of the patterns. [1] N.S. Rossen, J.M. Tarp, J. Mathiesen, M.H. Jensen and L.B. Oddershede, Nature Physics, under review (2014)

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