Tetsuya Kobayashi (University of Tokio, Institute of Industrial Science)
Fitness, defined by the long-term growth of a population, is the central quantity that characterizes the evolutionary success of the population macroscopically. The innovations of single-cell imaging and long-term tracking techniques have revealed a huge heterogeneities in populations of cells, and also enabled us to investigate how microscopic behaviors of the single cells are linked to the macroscopic properties of the population, including fitness. In addition, it has been revealed that the problem of the adaptation and evolution of growing populations shares a lot with the information thermodynamics and the steady state thermodynamics, suggesting that we can use the knowledge in these fields for understanding the evolution. In this talk, I attempt to outline how the problems of evolution and thermodynamics are related. By highlight their similarities and differences, I am going to show the open problems and challenges in the evolution and adaptation at the cellular level.