Speaker
Description
In bacteria, gene regulation often involves transcription factor proteins that bind to short DNA regions (promoters) near the gene start to control expression. However, in higher organisms, gene activation is typically more complex and frequently depends on enhancer-promoter interactions. Enhancers and promoters are distant DNA elements that come together in 3D space to tune transcription. In this talk, I will show how we model the stochastic dynamics of these interactions using resetting theory. Our model allowed us to calculate experimentally accessible observables such as the mean-first hitting time. In addition, our theory aligns with empirical data from Drosophila and offers new insights into the physical principles underlying long-distance gene regulation.
