Understanding the fundamental nature of matter under extreme conditions is a captivating challenge in modern physics. Traditional methods, such as perturbation theory and lattice QCD, face significant limitations due to high computational costs or reliability issues. In contrast, the holographic principle offers a promising alternative. We develop an effective, albeit approximate, framework that captures the essential features of QCD at low energies. This approach not only provides valuable insights into the quark-gluon plasma and the dense matter within neutron stars but also bridges the gap to nuclear physics. We provide predictions for the equation of state and the most relevant transport phenomena, enhancing our understanding of such extreme matter.