Speaker
Enzo Marinari
(University of Rome La Sapienza)
Description
The analysis of non-equilibrium steady states of biochemical
reaction networks relies on finding the configurations of
fluxes and chemical potentials satisfying stoichiometric
(mass balance) and thermodynamic (energy balance)
constraints. Efficient methods to explore such states are
crucial to predict reaction directionality, calculate physiologic
ranges of variability, estimate correlations, and reconstruct
the overall energy balance of the network from the
underlying molecular processes. While different techniques
for sampling the space generated by mass balance
constraints are currently available, thermodynamics is
generically harder to incorporate. Here we introduce a
method to sample the free energy landscape of a reaction
network at steady state.
(in collaboration with Daniele De Martino, Matteo Figliuzzi,
Andrea De
Martino)
