23–26 May 2012
Ferry Stockholm-Mariehamn and Hotel Arkipelag, Mariehamn, Åland
Europe/Stockholm timezone

Search methods for tile sets in patterned DNA self-assembly

25 May 2012, 11:30
30m
Ferry Stockholm-Mariehamn and Hotel Arkipelag, Mariehamn, Åland

Ferry Stockholm-Mariehamn and Hotel Arkipelag, Mariehamn, Åland

Speaker

Dr Eugen Czeizler (Aalto University)

Description

We consider the problem of finding, for a given 2D pattern of coloured tiles, a minimal set of tiles assembling this pattern (in the abstract Tile Assembly Model of Winfree (1998)). This Patterned self-Assembly Tile set Synthesis (PATS) problem was first introduced by Ma and Lombardi (2008), and subsequently studied by Goos and Orponen (2010), who presented an exhaustive partition-search branch-and-bound algorithm. Later we shifted to the problem of finding small (maybe not minimal) and reliable solutions, in a reasonable time interval, Lempiainen et al. (2011). We modified the basic partition search framework by using a heuristic to optimize the order in which the algorithm traverses its search space. The new algorithm was able to shorten considerably the time needed for finding small (minimal, or close to minimal) tile sets. In a recent breakthrough, we showed that the PATS problem is NP hard by providing a reduction from the 3SAT problem. Thus, local search algorithms for PATS remain the default solution for finding acceptable solutions in a reasonable time interval.

Primary author

Dr Eugen Czeizler (Aalto University)

Presentation materials

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