Speaker
Prof.
Ulrich Gerland
(LMU)
Description
Enzymes within biochemical pathways are often colocalized,
yet the consequences of specific spatial enzyme arrangements
remain poorly understood. We study the impact of enzyme
arrangement on reaction efficiency within a
reaction-diffusion model. The optimal arrangement
transitions from a cluster to a distributed profile as a
single parameter, which controls the probability of reaction
versus diffusive loss of pathway intermediates, is varied.
We introduce the concept of enzyme exposure to explain how
this transition arises from the stochastic nature of
molecular reactions and diffusion.
Primary author
Prof.
Ulrich Gerland
(LMU)
