Prof.
Oskar Hallatschek
(MPI)
23/05/2013, 16:30
The spreading of evolutionary novelties across populations
is the central element of adaptation. Unless population are
well-mixed (like bacteria in a shaken test tube), the
spreading dynamics not only depends on fitness differences
but also on the dispersal behavior of the species. Spreading
at a constant speed is generally predicted when dispersal is
sufficiently short-ranged. However,...
Prof.
Mogens Hogh Jensen
(NBI)
23/05/2013, 17:15
Oscillating genetic patterns have been observed in networks
related to the transcription factors NFkB, p53 and Hes1 [1].
We identify the central feed-back loops and found
oscillations when time delays due to saturated degradation
are present. By applying an external periodic signal, it is
sometimes possible to lock the internal oscillation to the
external signal. For the NF-kB systems in...
Prof.
Ville Mustonen
(Sanger Centre)
23/05/2013, 18:15
Understanding the molecular basis of the adaptive evolution
of a population has relevance for important biological
questions. For example, the problem of identifying genetic
variants which underlie drug resistance, a question of
importance for the treatment of pathogens, and of cancer,
can be understood as a matter of inferring selection. A key
problem in discovering variants under...
