Speaker
Enzo Marinari
(Universita di Roma, La Sapienza, Rome)
Description
New experimental results on bacterial growth inspire a novel
top-down approach to study cell metabolism, combining flux
balance and proteomics constraints. Flux Balance Analysis
has been proven a very useful tool in modeling cellular
metabolism, but it is unable to capture features such as the
switch to anaerobic metabolism at high growth rates observed
in bacteria. We introduce the Constrained Allocation Flux
Bal-ance Analysis framework, CAFBA, which is able, among
others, to correctly reproduce the anabolic switch
