Generation and Control of Forces in Cells

11 Jun 2018, 09:00 → 29 Jun 2018, 18:00 Europe/Stockholm

122:026 (Nordita, Stockholm)

Anders Carlsson (Washington U in St Louis), David Sept (U of Michigan), Edda Klipp (Humboldt U)

Venue

Nordita, Stockholm, Sweden

Scope

The program will bring together a group of theoretical physicists, mathematicians, experimental biologists, and experimental biophysicists, to study the mechanisms by which i) protein assemblies, such as biopolymers, exert forces in cells, ii) protein assembly dynamics in cells are regulated by forces, and iii) the dynamics of force-generating assemblies are controlled by signaling pathways. The program will have an average attendance of about 20 scientists over a period of three weeks. It will enhance the formation of collaborative links between experiment and theory, as well as those between theorists using different methodologies. It will also clarify the links between apparently disparate, but related phenomena by bringing in individuals with a broad range of backgrounds. Finally, it will enhance the development of the mechanobiology community in the Nordic countries.

The workshop is open to researchers at all levels, including postdoctoral associates and students. Participants are expected to stay at least Monday-Friday of one week.

There is no registration fee.

To apply for the program, please use the "Application" link at upper left.

Monday, 11 June

10:00 → 11:00 Registration

11:00 → 11:10 Alison Patteson: A hitchhikers guide to cell motility - Nonlinear physics approach to swimming bacteria and crawling cells

11:10 → 11:15 Anders Carlsson: Membrane Bending by Actin Polymerization

11:15 → 11:20 Christoph Schmidt: Active biological matter - force generation and sensing

11:20 → 11:25 David Sept: Relating Structure and Function in Actin

11:25 → 11:30 Dhrubaditya Mitra: Measurement of probability density function of a elastic modulus of human RBCs

11:30 → 11:35 Fred MacKintosh: Mechanical phase transitions and collagen rheology

11:35 → 11:40 Garegin Papoian: Theory of Active and Passive Force Dipoles in Contractile Acto-Myosin Networks

11:40 → 11:45 Guy Genin: Interactions of plant and animal cells with their local microenvironments

11:45 → 11:55 Hudson Borja Da Rocha: Functionality of disorder in muscle mechanics

11:55 → 12:00 Inari Kursula: Peculiar actins in apicomplexan parasites?

13:30 → 13:35 Jen Schwarz: On the compressional stiffening of a cell

13:35 → 13:40 John Cooper: Septins support actin-based lamellipodial protrustions

13:40 → 13:50 Juha Vahokoski: Plasmodium Myosin A, the core component in motility of the malaria parasite

13:50 → 14:00 Kengo Nishi: Dynamics of semi-flexible filament in viscoelastic media: Microrheology using semiflexible polymer

14:00 → 14:05 Lev Truskinovsky: Mechanical stress as a regulator of cell motility

14:05 → 14:15 Marzeh Saeedimasine: Study on the mechanical properties of the axonal membrane

14:15 → 14:20 Mikael Oliveberg: Lessons from transferring proteins across divergent organisms

14:20 → 14:25 Moumita Das: Structure-function properties of cytoskeletal and ECM networks: mechanics and crack propagation

14:25 → 14:30 Paul Janmey: How good are polymer networks as models for tissue mechanics

14:30 → 14:40 Renata Garces: Passive and active response of bacteria under mechanical compression

14:40 → 14:50 Setareh Dolati: Force and density relation in lamellipodial protrusion

Tuesday, 12 June

09:00 → 10:00 Response of polymer networks, cells, and tissues to compression and stretch

Speaker: Prof. Paul Janmey

10:30 → 11:30 Mechanical phase transitions and collagen rheology

Speaker: Prof. Fred MacKintosh

14:00 → 15:00 Structure-function properties of cytoskeletal and ECM networks: mechanics and crack propagation

Speaker: Moumita Das (Rochester Institute of Technology)

15:30 → 16:30 Competing forces in contracting cardiomyocytes

Speaker: Christoph Schmidt (University of Göttingen)

Wednesday, 13 June

09:00 → 10:00 Interactions of plant and animal cells with their local microenvironments

Speaker: Guy Genin (Washington University in St Louis)

10:30 → 11:30 Active rigidity

Speaker: Lev Truskinovsky (ESPCI Paris)

Thursday, 14 June

09:00 → 10:00 Peculiar actins in apicomplexan parasites?

Speaker: Inari Kursula (University of Bergen)

10:30 → 11:30 Relating Structure and Function in Actin

Speaker: David Sept

14:00 → 15:00 The cell cytoskeleton and the cell nucleus: A tale of two interacting active environments

Speaker: Jennifer Schwarz (University of Syracuse)

Friday, 15 June

09:00 → 10:00 Directed Actin Cytoskeleton Self Organization, Contractility and Motility

Speaker: Laurent Blanchoin (CNRS Grenoble)

10:30 → 11:30 Self organization in cytoskeletal systems

Speaker: Andreas Bausch (Technische Universität München)

Monday, 18 June

10:00 → 11:00 Registration

11:00 → 11:05 Alex Mogilner: Self-organized actomyosin transport

11:05 → 11:10 Anders Carlsson: Membrane Bending by Actin Polymerization

11:10 → 11:15 Andreas Bausch: Self organization in cytoskeletal systems

11:15 → 11:20 David Sept: Relating Structure and Function in Actin

11:25 → 11:30 Fred MacKintosh: Mechanical phase transitions and collagen rheology

11:35 → 11:40 Garegin Papoian: Theory of Active and Passive Force Dipoles in Contractile Acto-Myosin Networks

11:40 → 11:45 Guillaume Romet-Lemonne: Regulating actin filament assembly with proteins and forces

11:45 → 11:55 Hugo Wioland: Impact of mechanics on actin filament disassembly by ADF/cofilin.

11:55 → 12:00 Inari Kursula: Peculiar actins in apicomplexan parasites?

13:30 → 13:35 Inke Näthke: Mechanics in the gut epithelium

13:35 → 13:40 John Cooper: Septins support actin-based lamellipodial protrusions

13:40 → 13:45 Kristen Verhey: Force generation by kinesin motors in a cellular context

13:45 → 13:50 Laurent Blanchoin: Directed Actin Cytoskeleton Self Organization, Contractility and Motility

13:50 → 13:55 Lene Oddershede: Role of biomechanics in stem cell differentiation and organ development

13:55 → 14:05 Lucia Baldauf: Cell division from the bottom up: Influence of membrane attachment on actomyosin contractility

14:05 → 14:15 Marzeh Saeedimasine: Study on the mechanical properties of the axonal membrane

14:15 → 14:20 Mikael Oliveberg: Lessons from transferring proteins across divergent organisms

14:20 → 14:25 Moumita Das: Structure-function properties of cytoskeletal and ECM networks: mechanics and crack propagation

14:25 → 14:30 Rob Cross: Novel aspects of the walking mechanism of kinesin

14:30 → 14:35 Taeyoon Kim: Force generation and contractile behaviors of the actin cytoskeleton

14:35 → 14:40 Vivek Shenoy: Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models

14:40 → 14:45 Martin Falcke: Coupling between F-actin network structure and polymerization rate: Do we need to take it into account?

Tuesday, 19 June

09:00 → 10:00 Self-organized actomyosin transport

Speaker: Alex Mogilner (New York University)

10:30 → 11:30 Coupling between F-actin network structure and polymerization rate: Do we need to take it into account?

Speaker: Martin Falcke (Max Delbrück Center for Molecular Medicine, Berlin)

14:00 → 15:00 Mechanics in the gut epithelium

Speaker: Inke Näthke (University of Dundee)

15:30 → 16:30 Role of biomechanics in stem cell differentiation and organ development

Speaker: Lene Oddershede (Niels Bohr Institute, Copenhagen)

Wednesday, 20 June

09:00 → 10:00 Force generation by kinesin motors in a cellular context

Speaker: Kristen Verhey (University of Michigan)

10:30 → 11:30 Novel aspects of the walking mechanism of kinesin

Speaker: Rob Cross (University of Warwick)

Thursday, 21 June

09:00 → 10:00 Cell-Matrix Interactions in Fibrosis and Cancer: Multiscale mechano-chemical models

Speaker: Vivek Shenoy (University of Pennsylvania)

10:30 → 11:30 Regulating actin filament assembly with proteins and forces

Speaker: Guillaume Romet-Lemonne (Institute Jacques Monod, Paris)

14:00 → 15:00 Yeast Mating in space and time

Speaker: Edda Klipp (Humboldt-Universität, Berlin)

Monday, 25 June

10:00 → 11:00 Registration

11:00 → 11:10 Alfredo Sciortino: Formin-mediated actin polymerisation on supported lipid bilayers

11:10 → 11:20 Amma Abdalla Mohammed Khalid: Active matter: MT-Kinesin network studies

11:20 → 11:25 Anders Carlsson: Membrane Bending by Actin Polymerization

11:25 → 11:35 Benham Amiri: A 2D free-boundary model of actin-based force generation at the leading edge of motile cells.

11:35 → 11:40 David Sept: Relating Structure and Function in Actin

11:40 → 11:45 Dhrubaditya Mitra: Measurement of probability density function of a elastic modulus of human RBCs

11:45 → 11:50 Dimitrios Vavylonis: Modeling Actin Dynamics in Cell Motility and Cell Division

11:50 → 11:55 Enrique De La Cruz: How cofilin severs an actin filament.

11:55 → 12:00 Garegin Papoian: Theory of Active and Passive Force Dipoles in Contractile Acto-Myosin Networks

13:30 → 13:35 Henrik Flyvbjerg: How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time

13:35 → 13:40 Inke Näthke: Mechanics in the gut epithelium

13:40 → 13:45 Janusz Strzelecki: Extreme stretching of DNA

13:45 → 13:50 John Cooper: Septins support actin-based lamellipodial protrustions

13:50 → 14:00 Koji Kinoshita: Cell membrane mechanosensing study by using micropipette manipulation techniques

14:00 → 14:05 Luciana Bruno: Active Forces in Living Cells: Interplay between Microtubule Buckling and Organelle Transport.

14:05 → 14:15 Marzeh Saeedimasine: Study on the mechanical properties of the axonal membrane

14:15 → 14:20 Mikael Oliveberg: Lessons from transferring proteins across divergent organisms

14:20 → 14:25 Pranav Madhikar: Coarse-Grained Model for Cell Behaviour and Tissue Growth

14:25 → 14:35 Somanna Kollimada Aiyappa: Studying cellular actin dynamics in stress fibers using photoconversion

14:35 → 14:40 Taeyoon Kim: Force generation and contractile behaviors of the actin cytoskeleton

14:40 → 14:45 Zahra Mostajeran: Measuring dynamics of the actin filaments by FRAP in cells with a different amount of vimentin

Tuesday, 26 June

09:00 → 10:00 Lessons from transferring proteins across divergent organisms

Speaker: Mikael Oliveberg (Stockholm University)

10:30 → 11:30 Actin assembly at membranes: regulation and targeting of heterodimeric actin capping protein

Speaker: John Cooper (Washington University School of Medicine)

14:00 → 15:00 Force generation and contractile behaviors of the actin cytoskeleton

Speaker: Taeyoon Kim (Purdue University)

15:30 → 16:30 Theory of active and passive force dipoles in contractile acto-myosin networks

Speaker: Garegin Papoian (University of Maryland)

Wednesday, 27 June

09:00 → 10:00 Cell membrane mechanosensing study by using micropipette manipulation techniques

Speaker: Koji Kinoshita (Syddansk Universitet, Denmark)

10:30 → 11:30 Measurement of probability density function of elastic modulus of human RBCs

Speaker: Dhrubaditya Mitra (NORDITA, Stockholm)

Thursday, 28 June

09:00 → 10:00 How cofilin severs an actin filament

Speaker: Enrique De La Cruz (Yale University)

10:30 → 11:30 Modeling Actin Dynamics in Cell Motility and Cell Division

Speaker: Dimitrios Vavylonis (Lehigh University)

14:00 → 15:00 Active forces in living cells: interplay between microtubule buckling and organelle transport

Speaker: Luciana Bruno (University of Buenos Aires)

Friday, 29 June

09:00 → 10:00 How to connect time-lapse recorded trajectories of motile microorganisms with dynamical models in continuous time

Speaker: Henrik Flyvbjerg (Technical University of Denmark)

10:30 → 11:30 Membrane bending by actin polymerization

Speaker: Anders Carlsson (Washington University in St Louis)