Speaker
Prof.
Aleksandra Walczak
(ENS)
Description
Recognition of pathogens relies on the diversity of immune
receptor proteins. Recent experiments that sequence the
entire immune cell repertoires provide a new opportunity for
quantitative insight into naturally occurring diversity and
how it is generated. The generation process is implemented
via a series of stochastic molecular events involving gene
choices and random nucleotide insertions between, and
deletions from, genes. I will describe how we can attempt to
quantify the diversity of the receptors formed in this
complex process and point to the origins of diversity in
these sequences.
Primary author
Prof.
Aleksandra Walczak
(ENS)
