Long-range ordered vorticity patterns induced by cell division

Mar 22, 2013, 9:30 AM
132:028 (Nordita)




Prof. Lene Oddershede (Niels Bohr Institute)


In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate is significantly increased during embryonic development and in unhealthy endothelium with halted or turbulent blood flows. Cells in a tissue are connected and their motility highly correlated. Here, we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or healing around blood clots. We demonstrate that a cell division induces a long-range ordered pattern of vortices in the monolayer. Two pairs of primary vortices arise adjacent to the dividing cell, and eight pairs of secondary and tertiary vortices appear several cell diameters away. The occurrence of ordered vortices is surprising considering the system's low Reynolds number and may be crucial for embryonic development and healing of endothelial tissue.

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