Speaker
Olivier Rivoire
Description
Proteins are very heterogeneous objects: they are sensitive to
perturbations at some sites distant from their active site while being
insensitive to perturbations at closer sites. These long-range effects
make decoding and engineering protein sequences particularly
challenging. I’ll review the evidence for the ubiquity of these long range
effects and discuss previous models aimed at understanding their
physical nature and evolutionary origin. This will motivate the
introduction of a new model where long-range effects emerge
spontaneously. I’ll explain how the model accounts for the evolution of
long-range regulation (allostery) and for the different patterns of
coevolution that may be inferred from protein sequences.
Primary author
Olivier Rivoire
