26–29 May 2010
Europe/Stockholm timezone

Modeling Viral Evolution in competition with the Immune System

27 May 2010, 15:15
45m

Speaker

Silvio Franz (Université Paris-Sud)

Description

Influenza viruses evolve at a high speed to escape acquired immunity and infect the same host several time. Contrary to naive expectation, this does not lead to a large diversity in the viral population. Phylogenetic studies show that the viral population display the characters of an "evolving quasispecies" with reduced instantaneous diversity. In this talk I will discuss a simple stochastic model of and evolving viral population that allows to rationalize the evolving quasispecies behavior as an emerging feature of the competition between strains with different level of infectivity.

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