19 September 2011 to 14 October 2011
Nordita
Europe/Stockholm timezone

Mean first passage times: Meaningful or meaningless?

27 Sept 2011, 14:00
45m
132:028 (Nordita)

132:028

Nordita

Speaker

Gleb Oshanin (Physique Theorique de la Matiere Condensee, Universite Pierre & Marie Curie, Paris)

Description

In many problems in physics, biophysics or chemistry one is often interested to know how fast a randomly moving ”particle” (a ligand, an ion, a protein, a reactant, a phage, etc) may find a particle of another species, a binding or a ”specific” site, an entrance/exit to a bounded domain, a receptor, a target, a source of odor, any ob ject in space, etc. A commonly used characteristic is the first moment of the first passage time distribution - the mean first passage time (MFPT), which in many cases can be evaluated or, at least, estimated analytically. The question is, however, how the MFPT is representative of an actual behavior. In the first, central part of this talk we overview some recent results [C. Mejia-Monasterio, G. Oshanin and G. Schehr, J. Stat. Mech. 2011 P06022 (2011)] for unbiased (centrally biased) Brownian search for an immobile target in bounded (or infinite) spherical domains. We use here a special novel ”diagnostic” of the first passage events: in our ”imaginary” experiment, instead of considering a single searcher, we launch simultaneously from the same point in space two absolutely identical non-interacting ones and calculate the distribution function P (ω) of a random variable ω = t1/(t1 + t2), where t1 and t2 are the (unordered) times of the first passage to the target for the searcher 1 and searcher 2, respectively. We show that P (ω) exhibits quite a non-trivial and sometimes a counterintuitive behaviour so that its very shape (a broad bell-shaped form with a maximum at ω = 1/2 or an M-like form with a minimum at ω = 1/2 and maxima close to 0 and 1) depends, remarkably, on the size of the system, the location of the starting point relative to the target and/or on the magnitude of the bias, if any. The shape of P (ω) appears also to be sensitive to the form of the domain: we demonstrate that for an infinite (finite) wedge or a 3D cone, or a triangle with adsorbing boundaries, the distribution P (ω) may have a bell-shaped or an M-like forms depending whether the value of the opening angle is less than or exceeds some critical value. Our results thus indicate that, despite the fact that the single-searcher first passage time distribution has moments of arbitrary order, the sample-to-sample fluctuations are very significant and the mean first passage time is not, in fact, a reliable measure of the first passage events. Further on, we will consider, within the framework of a model originally proposed by de Gennes [J. Stat. Phys. 12 463 (1975)], dynamics of a boundary separating the helix and coil phases in a partially melted heteropolymer bearing a random alphabet. For this model, a random variable ω is the alphabet-dependent probability that a randomly moving boundary will first hit the left extremity of the polymer (so that the chain will return to its native helix state) without having ever hit the right extremity, while t1 and t2 are the resistances of the two respective intervals to the left and to the right of the starting point. Hence, P (ω) is the probability distribution (averaged over all possible alphabets) of such a hitting probability. We show [G. Oshanin and S. Redner, EPL 85, 10008 (2009)] that also in this situation P(ω) exhibits a transition from a bell-shaped (for sufficiently short polymers) form to an M-like shape (for sufficiently long polymers). We therefore conclude that the evolution of a partially melted long random heteropolymer is controlled by the arrangement of monomers along the chain so that each heteropolymer realization has a unique kinetics and unique final fate that is not representative of the average behavior of an ensemble of such polymers. Finally, we will show that an analogous shape-reversal transition occurs in Black-Scholes model of stock options evolution. Considering two identical Black-Scholes stochastic equations, which produce two identical (uncorrelated or correlated) either European- or Asian-style options t1 and t2, we will demonstrate that the distribution function of the relative weight ω of either of the options in a portofolio composed of two such options undergoes at a certain moment of time a transition from a unimodal form with a maximum at ω = 1/2 to a bimodal form with a minimum at ω = 1/2, which reflects the symmetry breaking between two identical options [G. Oshanin and G. Schehr, Quantitative Finance, to appear; arXiv:1005.1760v2].

Primary author

Gleb Oshanin (Physique Theorique de la Matiere Condensee, Universite Pierre & Marie Curie, Paris)

Presentation materials

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