Speaker
Dr
Thomas Ouldridge
(Oxford University)
Description
We have recently proposed a coarse-grained model of DNA [1]
which captures much of the thermodynamic and physical
changes associated with DNA duplex formation from isolated
single strands, in particular representing double-stranded
hybridization, hairpin formation and single-stranded
stacking consistently for the first time. Despite this, the
model is suciently simple to allow the study of processes
occurring on long timescales, and as such provides access to
the physics of nanostructure formation and nanomachine
operation. Here we present the model, and explore
applications to DNA tweezers, a two-footed DNA walker and
DNA origami. [1] T. E. Ouldridge, A. A. Louis, and J. P. K.
Doye, Phys. Rev. Lett. 104, 178101 (2010).
Primary author
Dr
Thomas Ouldridge
(Oxford University)
