Speaker
Prof.
William Shih
(Harvard Medical School)
Description
I will present a general method for solving a key challenge
for nanotechnology: programmable self-assembly of complex,
three-dimensional nanostructures. Previously, scaffolded DNA
origami had been used to build arbitrary flat shapes 100 nm
in diameter and almost twice the mass of a ribosome. We have
succeeded in building custom three-dimensional structures
that can be conceived as stacks of nearly flat layers of
DNA. Successful extension from two-dimensions to
three-dimensions in this way depended critically on
calibration of folding conditions. This general capability
for building complex, three-dimensional nanostructures will
pave the way for the manufacture of sophisticated devices
bearing features on the nanometer scale.
Primary author
Prof.
William Shih
(Harvard Medical School)
