Statistical Mechanics and Computation of DNA Self-Assembly

Session

Ferry session

25 May 2011, 16:45

Hotel Arkipelag, Mariehamn, Finland

251. Finicky and Sloppy Molecular Beacons

Prof. Fred Kramer (Public Health Research Institute)

25/05/2011, 17:00

Molecular beacons are hairpin-shaped oligonucleotide probes that undergo a fluorogenic conformational change upon binding to PCR amplicons. They can be labeled with differently colored fluorophores, enabling multiplex assays to be carried out in sealed reaction tubes. They can be designed to be “finicky”, so that they only bind to amplicons from a single species, or they can be designed...

252. Sequence, shape, function: a primer to DNA origami

Prof. Hendrik Dietz (Technische Universität München)

25/05/2011, 18:45

Advanced molecular self-assembly with ‘DNA origami’ offers a unique route for building custom shaped high-complexity objects that are commensurate in size to biological macromolecules. DNA origami objects can be used as platforms for placing, orienting, and even manipulating biological molecules in user defined ways. Thus, DNA origami objects can not only help improve existing...