Modeling nucleosome mediated epigenetics

Feb 23, 2011, 10:15 AM
FB42 (AlbaNova Main Building)


AlbaNova Main Building


Kim Sneppen (NBI)


In the talk I will discuss how localized part of an eucaryotic genome can be bistable. Bistable systems open for epigentics, a central theme in regulation of living cells. It is demonstrated that both copperativity and non-local interactions along the DNA are needed to obtain bistability. Further various localization mechanisms are discussed, with aim of explaining how the system maintain boundaries between silenced and active regions along the chromosome.

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