Modeling nucleosome mediated epigenetics

Feb 23, 2011, 10:15 AM
45m
FB42 (AlbaNova Main Building)

FB42

AlbaNova Main Building

Speaker

Kim Sneppen (NBI)

Description

In the talk I will discuss how localized part of an eucaryotic genome can be bistable. Bistable systems open for epigentics, a central theme in regulation of living cells. It is demonstrated that both copperativity and non-local interactions along the DNA are needed to obtain bistability. Further various localization mechanisms are discussed, with aim of explaining how the system maintain boundaries between silenced and active regions along the chromosome.

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