Mar 23 – 24, 2009
KTH - Royal Institute of Technology
Europe/Stockholm timezone

Inflammatory and genotoxic effects of nanoparticles -Focus on nanoparticles used in the paint and lacquer industry

Mar 23, 2009, 1:15 PM
45m
F3 (KTH - Royal Institute of Technology)

F3

KTH - Royal Institute of Technology

Lindstedtsväg 26

Speaker

Dr Anne Thoustrup Saber (National Research Centre for the Working Environment, Copenhagen, Denmark)

Description

Different kinds of particles have been shown to induce genotoxic damage after deposition in the lung. This may result in cancer if the DNA damage is not repaired or if selective apoptosis of the damaged cells fails. A primary mechanism of particle-induced genotoxicity has been attributed to the surface characteristics. A decade ago a secondary pathway for genotoxicity was proposed on the basis of the finding that carbon black exposed rats developed tumours similar to DEP exposed rats, despite the fact that carbon black is almost devoid of PAH´s on the surface. The fact that tumour formation in rats has been found to be paralleled by the degree of chronic neutrophilic inflammation led to the idea about a relationship between particle-induced inflammation and genotoxicity. Likewise, most human cancers are accompanied by the infiltration of inflammatory cells and a wide range of chronic inflammatory diseases predispose to cancer in the affected organ. The genotoxic effect of particle-induced inflammation is related to the release of reactive oxygen species by the inflammatory process. It has been demonstrated that the inflammatory response depends on the particle size. Exposure studies have shown that ultrafine particles cause more inflammation in the lungs of rodents than exposure to the same mass concentration of fine particles. The greater surface area has been suggested to be responsible for the greater inflammatory response of the ultrafine particles. This is based on a linear correlation between surface area of relatively inert particles and inflammatory response measured by the total number of neutrophils in rats. Thus, the genotoxic effects of PM can either be directly due to surface properties of the particles or due to ROS released by the inflammatory process. I will discuss inflammatory and genotoxic effects of nanoparticles on the background of results obtained in an ongoing project, Nanokem. The aims of NanoKem are to identify and characterize the essential risks caused by exposure to nanoparticles in the paint- and lacquer industry.

Primary author

Dr Anne Thoustrup Saber (National Research Centre for the Working Environment, Copenhagen, Denmark)

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