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Statistical Mechanics and Computation of DNA Self-Assembly

25–28 May 2011
Hotel Arkipelag, Mariehamn, Finland
Europe/Stockholm timezone

Session

Statistical mechanics

2
26 May 2011, 09:00
Hotel Arkipelag, Mariehamn, Finland

Hotel Arkipelag, Mariehamn, Finland

Presentation materials

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  1. 253. Self-assembly of DNA into nanoscale three-dimensional shapes
    Prof. William Shih (Harvard Medical School)
    26/05/2011, 09:15
    I will present a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures. Previously, scaffolded DNA origami had been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome. We have succeeded in building custom three-dimensional structures that can be conceived as stacks...
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  2. 254. Assembly of single-walled carbon nanotubes on DNA-origami templates through streptavidin-biotin interaction
    Prof. Päivi Törmä (Aalto University)
    26/05/2011, 10:30
    I present work where we propose a novel method for the controlled positioning of carbon nanotubes on DNA self-assembled structures. The method is based on the use of streptavidin (STV)–biotin interaction. Precise assembly of both a single CNT and CNT cross-junctions on DNA-origami templates with relatively high yield is demonstrated. The results thus make an essential contribution to the...
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  3. 268. On the theory of cost and benefit - experiments and theory
    Prof. Erez Dekel (Weizmann Institute of Science)
    26/05/2011, 11:15
  4. 256. Free-form design of 3D DNA nanostructures using vHelix for Autodesk Maya
    Prof. Björn Högberg (Karolinska Institute)
    26/05/2011, 14:30
    CAD software for the design of 3D DNA origami nanostructures have been reported previously. In caDNAno by Shawn Douglas, and the more recent CanDo package by Castro and co-workers the focus has been on designing structures where parallel helices are packed in a square-, or honeycomb-lattice. In our recent efforts in building a DNA nanopore, there has been a need for a design software...
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  5. 257. Microfluidic tools for DNA analysis, manipulation and separation
    Dr Lukas Bogunovic (Universität Bielefeld)
    26/05/2011, 15:15
    We present our recent studies concerning micro-and nanofluidic devices that are capable of detecting, manipulating and separating single DNAs with different lengths and conformations [1,2] and with complexed molecules such as polymerases or chemotherapeutics [3,4]. The first device consists of a straight microchannel structured with an array of non-conducting posts, which create...
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  6. 258. Thermodynamics of RNA hybridization inferred from out of equilibrium unzipping experiments
    Dr Josep Maria Huguet (Universitat de Barcelona)
    26/05/2011, 16:30
    We have recently developed a methodology to infer the free energy of hybridization of DNA with a single molecule technique (Huguet et al., PNAS 107, 15431 (2010)). It consists in unzipping a molecule of DNA of a few thousands of base pairs with optical tweezers. These pulling experiments provide a force vs. distance curve that is analyzed to obtain the free energy of formation of...
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  7. 259. Coarse-grained modelling of DNA and DNA self-assembly
    Dr Thomas Ouldridge (Oxford University)
    26/05/2011, 17:15
    We have recently proposed a coarse-grained model of DNA [1] which captures much of the thermodynamic and physical changes associated with DNA duplex formation from isolated single strands, in particular representing double-stranded hybridization, hairpin formation and single-stranded stacking consistently for the first time. Despite this, the model is suciently simple to allow the study...
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